# Biohub ## About Biohub # Our mission is to cure or prevent all disease At Biohub, we build the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it. > With unprecedented scale of compute, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, Biohub is leading the first large-scale scientific initiative combining frontier AI with frontier biology. ## Introducing a world model of protein biology We’ve built an open discovery engine that makes biology computable — a space where billions of possible protein designs can be generated, tested, and refined on the basis of deep biological understanding. ## AI models for scientists and researchers We’re building frontier artificial intelligence for biology, trained on our vast and unique biological datasets, to better predict how human cells behave and how they can change. Scientists will use these models to craft new theories, design powerful experiments, and make breakthrough discoveries about human health and disease. The results will feed back into the AI models, improving their predictive ability — ultimately making it possible to solve disease. ## Frontier research to expand scientific knowledge The last decade of genomics and molecular research has generated significant insights into complex biological processes, but limits in technology and the sparsity of data in biology have hindered the application of AI. Our high-throughput data generation engines and discovery platforms will break through these barriers to help us answer some of the most complex questions in human biology. ### **Multi-dimensional imaging to measure, map, and model complex biological systems** We’re building imaging tools that capture life across scales — from single proteins to whole organisms — revealing how cells function, communicate, and assemble into living systems. These observations are laying the groundwork for a new generation of AI models that can predict cellular behavior and guide the development of better treatments for widespread diseases. The laser phase plate is poised to reveal the molecular machinery of life inside cells, at near-atomic detail. ### ****Decoding inflammation to advance human health**** Inflammation drives the most significant causes of death worldwide. We're building tools to enable precise molecular-level measurements of inflammation within human tissues in real time, and developing proactive, early interventions that can be deployed when inflammation first flares in the body. ### **Programming the immune system for early detection of disease** We’re developing AI models and engineered cells that harness our own immune cells to detect and ultimately treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’s, by delivering targeted treatment only when and where it is needed. ### **Accelerating rare disease research** By advancing the data, infrastructure, and partnerships that make translation faster and more scalable, we're accelerating the journey from basic discovery to patient benefit. ## Key Pages - [Research](https://biohub.org/research/) - [News](https://biohub.org/news/) - [Team](https://biohub.org/team/) - [Join Us](https://biohub.org/join-us/) - [Funding](https://biohub.org/funding/) - [Careers](https://biohub.org/careers/) - [Decoding inflammation](https://biohub.org/inflammation/) - [Immune cell reprogramming](https://biohub.org/immune-cell-reprogramming/) - [Imaging](https://biohub.org/imaging/) - [AI Models](https://biohub.org/ai-models/) ## Recent News & Updates - [GEN: Virtual Cells Go Multiscale to Predict Complex Biology](https://www.genengnews.com/topics/artificial-intelligence/virtual-cells-go-multiscale-to-predict-complex-biology/) - AI models inform therapeutics that can restore diseased cells to healthy states - [Protein Modeling, Cell Imaging and Patient-Powered Science: Reflections on Biohub’s Start to the Year](https://biohub.org/blog/priscilla-chan-2026-biohub-update/) - Co-founder Priscilla Chan shares reflections following Aspen Ideas: Health on the models, tools, and people driving Biohub's progress this year. - [Surprising drug targets for psoriasis emerge from comprehensive CRISPR study of human skin cells](https://biohub.org/news/psoriasis-drug-targets-crispr-screen/) - Analysis of results by AI ‘novelty filter’ led researchers to formulate topical gels that, in mice, were as effective as widely used injected therapy. - [From patient communities to precision treatments: harnessing AI-powered biology for rare disease](https://biohub.org/blog/ai-powered-biology-rare-disease/) - [Science: Laser-boosted microscopes could reveal new drug targets, sharpen views inside cells](https://www.science.org/content/article/laser-boosted-microscopes-could-reveal-new-drug-targets-sharpen-views-inside-cells) - Enhanced cryo–electron microscopy promises to bring previously elusive proteins into view - [C&EN: A new, ultrabright laser powers a cryo-EM advance 15 years in the making](https://cen.acs.org/analytical-chemistry/microscopy/laser-phase-plate-cryo-electron-microscopy-advance/104/web/2026/06) - Phase contrast enables structures of smaller proteins, could drive in-cell proteomics - [Making the invisible visible](https://biohub.org/blog/laser-phase-plate-cryo-em-making-invisible-visible/) - A landmark achievement in microscopy is poised to reveal the molecular machinery of life inside cells, at near-atomic detail. - [Microscope Breakthrough Will Open Unprecedented View into Our Cells](https://biohub.org/news/laser-phase-plate-microscope-breakthrough/) - Biohub and UC Berkeley show that the laser phase plate, a revolutionary device with a laser 100 million times brighter than the Sun, dramatically improves images obtained through cryo-electron microscopy, giving scientists a new window into the molecular underpinnings of disease - [Nature: Move over, AlphaFold: open source model predicts shape of 1 billion proteins](https://www.nature.com/articles/d41586-026-01686-3) - The new open-source atlas, generated by an AI tool called ESMFold2, vastly increases the known protein universe. - [Biohub releases a world model of protein biology](https://biohub.org/news/world-model-of-protein-biology/) - Biohub’s open models map the protein universe and design functional binders with therapeutic-level affinity in the lab. ## Categories - [AI](https://biohub.org/blog/category/ai/) - [Data](https://biohub.org/blog/category/data/) - [Imaging](https://biohub.org/blog/category/imaging/) - [Immune cell reprogramming](https://biohub.org/blog/category/immune-cell-reprogramming/) - [Other](https://biohub.org/blog/category/uncategorized/) - [Technology](https://biohub.org/blog/category/technology/) - [Tissue instrumentation & inflammation](https://biohub.org/blog/category/tissue-instrumentation-inflammation/) - [Translational impact & engagement](https://biohub.org/blog/category/translational-impact-engagement/) ## News Categories - [News](https://biohub.org/blog/news_categories/news/) ## Network Sites - [Royer Group](https://biohub.org/royer/) - Organismal Architecture - [Computational Microscopy](https://biohub.org/comp-micro/) - [Genomics](https://biohub.org/genomics/) - [Rapid Response](https://biohub.org/rapid-response/) - [Leonetti Group](https://biohub.org/leonetti/) - Intracellular Architecture - [Mass Spectrometry](https://biohub.org/mass-spec/) - [Balla Group](https://biohub.org/balla/) - Organismal Infection Biology - [Bioengineering](https://biohub.org/bioengineering/) - [Arias Group](https://biohub.org/arias/) - Virus-Host Interactions - [Jacobo Group](https://biohub.org/jacobo/) - Quantitative Tissue Morphogenesis - [Computational Biology](https://biohub.org/comp-biology/) - [Protein Science](https://biohub.org/pak/) - [Software Engineering](https://biohub.org/software-engineering/) - [Mass Spec Omics](https://biohub.org/mass-spec-omics/) - [Spatiotemporal Omics](https://biohub.org/spatiotemporal-omics/) - Daniel Wang - [eBooks](https://biohub.org/ebook/) - [Scientific Compute](https://biohub.org/scientific-compute/) - [Tissue Models](https://biohub.org/tissue-models/) - [Functional Immunogenomics](https://biohub.org/functional-immunogenomics/) - [Cardiac Biointerface Engineering](https://biohub.org/cardiac-biointerface-engineering/) - [Biomimetronics](https://biohub.org/biomimetronics/) - Csaba Forro - [Immune Cell Dynamics and Function](https://biohub.org/immune-cell-dynamics/) - Roham Parsa - [Advanced Single Cell Technology Platform](https://biohub.org/single-cell-technology-platform/) - Tim Olsen - [Immune Cell Engineering and Development](https://biohub.org/immune-cell-engineering/) - Sjoukje van der Stegen - [Proteoform Spatial Biology](https://biohub.org/proteoform-spatial-biology/) - Anthony Cesnik - [Synthetic Spatial Omics](https://biohub.org/synthetic-spatial-omics/) - Decoding and engineering cell state dynamics through spatial organization - [Dynamic Structural Cell Biology](https://biohub.org/dynamic-structural-cell-biology/) - We are building new imaging hardware and software tools to reveal the mysteries of our cells within their native context and obtain deep insights into the architecture of complex biological systems at the molecular level.