Publications

We developed a novel approach for the efficient delivery of nucleic acids into zebrafish embryos by lipid-based transfection. Our protocol bypasses the need for microinjection, offering a cost-effective, highthroughput, and user-friendly alternative. This protocol outlines new strategies for gene delivery in zebrafish to enhance the efficiency and scope of genetic studies in this model system.

Sensory hair cells of the auditory, vestibular, and lateral-line systems are highly directional in their mechanical responsiveness. We demonstrate that the polarization of hair cells in the larval zebrafish is specified through Notch1a-mediated lateral inhibition between pairs of developing cells.