November 6, 2025
Launching the first large-scale scientific initiative combining frontier AI with frontier biology to solve disease
To power this initiative, we are uniting our scientific teams as a single organization: Biohub.
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ESM3: Simulating 500 million years of evolution with a language model
ESM3 is the first generative model for biology that simultaneously reasons over the sequence, structure, and function of proteins.
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ESM Cambrian: Revealing the mysteries of proteins with unsupervised learning
ESM Cambrian is a next-generation language model trained on protein sequences at the scale of life on Earth, defining a new state of the art for protein representation learning.
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Axios: Zuckerberg and Chan bet AI can cure all disease
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Associated Press: Zuckerberg, Chan shift bulk of philanthropy to science, focusing on AI and biology to curb disease
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Science: AI drives dramatic expansion of Chan Zuckerberg Initiative’s funding to end all diseases
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Latent Space: Priscilla Chan and Mark Zuckerberg — Frontier AI + virtual biology to solve all diseases
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a16z Podcast: Mark Zuckerberg & Priscilla Chan — How AI will cure all disease
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Biohub launches first large-scale scientific initiative combining frontier AI with frontier biology to cure or prevent disease
Biohub to unite data, compute, experimental science, and AI to transform and accelerate scientific research.
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An update from our founders
We're going all in on AI-powered biology for our next chapter.
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Launching the first large-scale scientific initiative combining frontier AI with frontier biology to solve disease
To power this initiative, we are uniting our scientific teams as a single organization: Biohub.
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Genomics research for all
VariantFormer is the first deep learning model characterizing cross-tissue gene expression by bridging sequence-based modeling across genomes with population-based modeling across personalized genomes.
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Modeling cellular diversity
scLDM, a deep generative AI model of transcriptomics, generates realistic single-cell data to accelerate virtual cell research.