Ground Truths podcast with Eric Topol: AI-powered virtual cells are ‘the Holy Grail of biology’

Steve Quake, Eric Topol and Charlotte Bunne talk on a Zoom call.
(Left to right) Steve Quake, Eric Topol and Charlotte Bunne talk about the importance of virtual cell models on Eric Topol’s “Ground Truths” podcast.
, , ,

AI is going to provide the ability to make a transformative computational tool for biology. Right now, cell biology is 90% experimental and 10% computational … and AI can invert that ratio,” shared Steve Quake, Chan Zuckerberg Initiative’s head of science.

In the “Ground Truths” podcast, cardiologist, scientist and author Eric Topol spoke with Quake and Charlotte Bunne, assistant professor at Swiss Federal Technology Institute of Lausanne, about a shared vision for building AI-powered virtual cells — a challenge they describe as the “holy grail” of biology. Their conversation was built on a perspective piece in Cell outlining a roadmap for constructing virtual cell models that can simulate and predict cell behavior. They also discussed CZI’s role in leading development of AI virtual cell models that accelerate science and will become the catalyst for curing, preventing and managing all diseases.

Watch or listen to the full discussion.

###

About the Chan Zuckerberg Initiative
The Chan Zuckerberg Initiative was founded in 2015 to help solve some of society’s toughest challenges — from eradicating disease and improving education, to addressing the needs of our local communities. Our mission is to build a better future for everyone. For more information, please visit chanzuckerberg.com.

News

  • The Scientist: Three Amino Acids Improve Lipid Nanoparticle Therapy Delivery to Cells

  • Simple ‘Cocktail’ of Amino Acids Dramatically Boosts Power of Anti-Inflammatory mRNA Therapies and CRISPR Gene Editing

    Adding three common amino acids to lipid nanoparticle injections increased mRNA delivery up to 20-fold, pushed gene editing efficiency to nearly 90%, and suppressed inflammation in a model of acute liver disease.

  • New tool reveals how T cell responses evolve across organs

    By tracking recently activated T cells over time and across tissues, researchers uncover immune dynamics that may inform future therapies for infection, cancer, and autoimmunity