Event Overview
Presented by the Chan Zuckerberg Biohub San Francisco in partnership with the Chan Zuckerberg Initiative.
Sleep is critical for health and chronic sleep deprivation increases risk for virtually all diseases. Despite this, we know very little about what sleep is and how it’s regulated. This symposium will explore our understanding of sleep physiology and basic biology related to sleep. It will also review the contributions genetics is making toward understanding sleep regulation and sleep disorders. Emerging technical tools are contributing to our ability to better understand sleep. And increasing knowledge about molecular and circuit level regulation of sleep will ultimately enable more rational approaches to improving sleep in patients with sleep disorders.
Program
Wednesday, January 15
Welcome to Sleep Symposium
BASIC BIOLOGY
Sleep and synaptic homeostatis
Chiara Cirelli, University of Wisconsin-Madison
A motor theory of sleep-wake control
Yang Dan, University of California, Berkeley & Howard Hughes Medical Institute
Fluorescent polysomnography for single cell resolution whole-body comprehension of sleep
Philippe Mourrain, Stanford University
The impact of sleep on oxidative stress
Mimi Shirasu-Hiza, Columbia University
SLEEP AND CIRCADIAN RHYTHM GENETICS AND PHYSIOLOGY
Is a broken clock right twice a day? Regulation of sleep and waking functions by the circadian timing system
Jeanne Duffy, Harvard University
Genetics and biology of human circadian regulation
Louis Ptáček, University of California, San Francisco
Sleep and the human brain
Matthew Walker, University of California, Berkeley
Understanding sleep efficiency
Ying-Hui Fu, University of California, San Francisco
Large-scale direct neurophysiology and modulation of sleep dynamics in humans
Matthew Leonard, University of California, San Francisco
GENETICS/PATHOPHYSIOLOGY OF SLEEP DISORDERS
Insomnia – blame is all on restless legs syndrome?
Juliane Winkelmann, Technical University Munich & Helmholtz Zentrum Munich, Institute of Neurogenomics
A mechanism for sleep instability during aging
Luis de Lecea, Stanford University
Genetics of sleep disorders: from gene discovery towards biology and clinical translation
Richa Saxena, Harvard University
Chicken or egg?: sleep, clocks, and neurodegeneration
Yo-El Ju, Washington University
Poster Session/Reception
Thursday, January 16
THERAPIES FOR SLEEP DISORDERS
Mechanism matters: the effects of insomnia drugs that are wake promoting neurotransmitter receptor antagonists vs. GABA-A allosteric modulators
Andrew Krystal, University of California, San Francisco
Novel tailored therapies for sleep apnea treatment and management: A respiratory phenotyping precision medicine approach
Danny Eckert, Flinders University
Lightning Talks
Lightning Talks
SLEEP ENGINEERING/TECHNOLOGY
Mechanism matters: the effects of insomnia drugs that are wake promoting neurotransmitter receptor antagonists vs. GABA-A allosteric modulators
Andrew Krystal, University of California, San Francisco
Novel tailored therapies for sleep apnea treatment and management: A respiratory phenotyping precision medicine approach
Danny Eckert, Flinders University
Lightning Talks
Lightning Talks
Future trends in sleep research and medicine
Emmanuel Mignot, Stanford University
Proteomic biomarkers of circadian rhythm and sleep debt
Aditya Ambati, Stanford University
Sleep tech: crossing the intimacy threshold
Jonathan Berent, Google X
Panel Discussion
Moderator: Katja Brose, Chan Zuckerberg Initiative
Panelists:
• Jonathan Berent, Google X
• Yang Dan, University of California, Berkeley & Howard Hughes Medical Institute
• Emmanuel Mignot, Stanford University
• Louis Ptáček, University of California, San Francisco
• Richa Saxena, Harvard University
Presented in Partnership With

